Our research aims to gain detailed and molecular understanding of fundamental epigenetic processes. In particular, we are investigating how the chemical modifications of chromatin are functionally translated in a cellular environment. Here, our focus is on specialized proteins, RNAs and small cellular signaling molecules. To address the complex interplay of these factors from multiple angles, our laboratory is applying highly interdisciplinary approaches. These include advancing technologies for establishing and analyzing complex chromatin systems in the test tube by applying biochemistry and biophysics, molecular and cellular biology studies of tissue culture cells and the small nematode C. elegans for investigating essential chromatin components and global and systematic analyses of the general modules and networks of epigenetic regulation.

To obtain significant insights into​ chromatin regulation, our work aims to span the gap between complex studies of cellular and organismal systems in vivo and molecular analyses of recombinant and synthetic components in vitro. ​Our approach to the ‘biochemistry of epigenetic phenomena’ is highly multidisciplinary and is centered around the following research themes:​    

  • Recruitment mechanisms and regulation of multi-domain reader proteins of chromatin modifications: UHRF1
  • Regulation of chromatin structure and function by nuclear phosphatidylinositol phosphates
  • Molecular dissection of the DNA maintenance methylation machinery and its link to lipid metabolism
  • Analyzing the biological role of proteins binding to chromatin marks
  • Interplay of linker histones and H3 modifiability
  • Reconstitution and analysis of complex chromatin systems in vitro

For more details, pelase refer to our laboratory’s main webs site: 

LAB TEAM MEMBERS

Principal Investigator, Professor of Bioscience

Contact Email: wolfgang.fischle@kaust.edu.sa

Research Scientist

Main research project: Integrated computational approaches for understanding chromatin organization

Contact email: alaguraj.veluchamy@kaust.edu.sa

Postdoctoral Researcher

Main research project: Structual and functional analysis of the Interplay of linker histones and H3 modifiability

Contact email: dulat.azhibek@kaust.edu.sa​

Postdoctoral Researcher

Main research project: Recruitment mechanisms and regulation of multi-domain reader proteins of chromatin modifications: molecular analysis of the interaction of UHRF1 with PI5P

Contact email: papita.mandal@kaust.edu.sa​

Postdoctoral Researcher

Main research project: Regulation of chromatin structure and function by nuclear phosphatidylinositol phosphates: analysis of the global chromatin function of PIPs

Contact email: sarah.kreuz@kaust.edu.sa​

Postdoctoral Researcher

Main research project: Analyzing the biological role of proteins binding to chromatin marks: the C. elegans LIN-13, LIN-61, HPL-2 complex

Contact email: yogeshkumar.ostwal@kaust.edu.sa​

PhD Student

Main research project: Recruitment mechanisms and regulation of multi-domain reader proteins of chromatin modifications: cell cycle regulation of UHRF1

Contact email: bothayna.gashgari.1@kaust.edu.sa​

PhD Student

Main research project: Analyzing the biological role of proteins binding to chromatin marks: the role of HPL-2 on genome organization in C. elegans

Contact email: elizabeth.miller@kaust.edu.sa​

PhD Student

Main research project: Interplay of linker histones and H3 modifiability in stem cell differentiation

Contact email: fernanda.vargasromero@kaust.edu.sa​

PhD Student

Main research project: Molecular dissection of the DNA maintenance methylation machinery and its link to lipid metabolism

Contact email: jorge.landgravegomez@kaust.edu.sa​

PhD Student

Main research project: Regulation of chromatin structure and function by nuclear phosphatidylinositol phosphates: defining nuclear PI5P interactions

Contact email: othman.alahmed@kaust.edu.sa​

PhD Student

Main research project: Reconstitution and analysis of complex chromatin systems in vitro

Contact email: zhadyra.yerkesh@kaust.edu.sa​

Master Student

Main research project: Recruitment mechanisms and regulation of multi-domain reader proteins of chromatin modifications: conformational regulation of UHRF1

Contact email: aaron.pantojaangles@kaust.edu.sa​

Directed Research Student

Main research project: Regulation of chromatin structure and function by nuclear phosphatidylinositol phosphates: systems for manipulating nuclear PI5P levels

Contact email: mohammed.alomari@kaust.edu.sa​

Laboratory Manager

Contact email: bronagh.hogan@kaust.edu.sa​

Laboratory Assistant

Contact email: priethika.hewage@kaust.edu.sa​

Technician

Contact email: shakila.zahir@kaust.edu.sa​